Reference information only. Not medical, legal, or personal advice. Review our full disclaimer before relying on this page.
Harm Reduction

Interaction Checker

Pick a substance or a medication/condition. Both views show severity, clinical context, and a citation for each pair.

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By substance

LSD Long-acting classical psychedelic (8 to 12 hours).

  • Caution
    SSRIs
    SSRIs blunt and destabilize the LSD effect; a small washout under clinician supervision is the standard psychiatric guidance. Erowid: LSD health interactions
  • Caution
    SNRIs
    SNRIs (venlafaxine, duloxetine) carry the same serotonergic dampening and added blood pressure interaction as SSRIs. Drugs.com: LSD interactions
  • Avoid
    MAOIs
    MAOIs combined with classical psychedelics amplify serotonergic load and have been tied to hypertensive crisis in the case literature. Erowid: LSD health interactions
  • Caution
    Lithium
    Lithium with classical psychedelics is associated with case reports of seizures and adverse psychological events; clinician-supervised washout is advised. Psychiatric Times: Lithium and classical psychedelics (Robinson & Belser, 2022)
  • Avoid
    Tramadol
    Tramadol is serotonergic and lowers seizure threshold; combined with LSD, the serotonergic and seizure risks compound. Drugs.com: Tramadol interactions
  • Insufficient data
    Blood pressure medication
    Limited clinical data exists for LSD combined with antihypertensives outside monitored sessions; non-clinical use is not well characterized. JAMA Psychiatry: Psilocybin blood pressure in clinical trials
  • Insufficient data
    Antiepileptics (lamotrigine, carbamazepine)
    Lamotrigine dampens psychedelic intensity by sodium-channel activity; carbamazepine is a strong CYP3A4 inducer and unpredictably alters metabolism. Erowid: LSD health interactions
  • Caution
    Tyramine-rich foods (cheese, cured meats, fermented products)
    Tyramine-rich foods are not a meaningful direct interaction with LSD, but on MAOIs they are a contraindication; the combination flags here is theoretical caution only. Erowid: LSD health interactions
  • Caution
    Stimulants (amphetamine, methylphenidate, cocaine)
    LSD with amphetamines or cocaine increases cardiovascular strain and is tied to overstimulation and harder-to-redirect experiences. Erowid: LSD health interactions
  • Caution
    Alcohol and benzodiazepines
    Alcohol and benzodiazepines dull and destabilize the LSD experience; benzos are also a common "abort" route that can leave users oversedated. Erowid: LSD health interactions
  • Avoid
    Pregnancy and breastfeeding
    Pregnancy and breastfeeding warrant deferring any non-medical psychedelic use until clinical guidance or full postpartum clearance. MAPS: Ibogaine clinical FAQ
  • Caution
    Cardiovascular conditions (hypertension, arrhythmia, valve disease)
    Arrhythmia, valve disease, and uncontrolled hypertension make the cardiovascular load of LSD harder to monitor outside a clinic. JAMA Psychiatry: Psilocybin blood pressure in clinical trials
  • Avoid
    Personal or family psychotic-spectrum history
    A personal or first-degree psychotic-spectrum history is the standing contraindication for non-clinical psychedelic use across the literature. Lancet Psychiatry: Psychosis risk in psychedelic use

Compiled from MAPS clinical guidelines, the Erowid interaction vaults, Drugs.com interaction monographs, and recent peer-reviewed interaction literature. Use this as a starting point, not a substitute for medical advice; review our /disclaimer. Read the full disclaimer.

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